The preparation of organolithium reagents and intermediates methods such as the reductive ether cleavage1b or the selenium/lithium1c and tin/lithium1d permutations are referred to a recently edited Handbook1. Organolithium reagents are organometallic compounds that contain carbon – lithium bonds. Because of this they cannot be used as nucleophiles on compounds which contain acidic hydrogens. As discussed above, Grignard and organolithium reagents are powerful bases. They are important reagents in organic synthesis, and are frequently used to transfer the organic group or the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. II. If they are used they will act as a base and deprotonate the acidic hydrogen rather than act as a nucleophile and attack the carbonyl.